Over half of the annual 5.9 million under five deaths occurred in Sub-Saharan Africa (SSA), the majority from sepsis, which is the final common inflammatory pathway for most infectious disease-related deaths. Pediatric sepsis is preventable and treatable, and prompt recognition and early therapy can impact survival. Yet, sepsis remains a serious, life-threatening condition and we lack a robust understanding of how to manage pediatric sepsis in SSA due to limited regional data. Relative to high-income countries (HICs), very little data is generated in low-income countries (LICs). Frequently, LICs must rely on guidelines produced in and based on data generated in HICs, despite the fact that LICs have a distinct patient population and unique resource constraints. These data are critical to identify high-risk patients, develop triage systems and reduce barriers to care.